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Nanodiamonds in cancer treatment
By ISTO É FTP U.S. researchers said on Wednesday (09/03) the discovery of a way to attack tumors in advanced stages of breast cancer and liver, using a potent chemotherapy drug combined with tiny carbon particles known as nanodiamonds. The technique was tested in mice and showed that nanodiamonds help the doxorubicin to penetrate in […]
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Nucleosomes Containing Methylated DNA Stabilize DNA Methyltransferases 3A/3B and Ensure Faithful Epigenetic Inheritance
Read the study published in PLoS Genetics How epigenetic information is propagated during somatic cell divisions is still unclear but is absolutely critical for preserving gene expression patterns and cellular identity. Here we show an unanticipated mechanism for inheritance of DNA methylation patterns where the epigenetic mark not only recruits the catalyzing enzyme but also […]
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Male pattern baldness and the risk of prostate cancer
Annals of Oncology Background: Androgens play a role in the development of both androgenic alopecia, commonly known as male pattern baldness, and prostate cancer. We set out to study if early-onset androgenic alopecia was associated with an increased risk of prostate cancer later in life. Patients and methods: A total of 669 subjects (388 with […]
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BCR–ABL-mediated upregulation of PRAME is responsible for knocking down TRAIL in CML patients
Of Oncogene Tumor necrosis factor-related apoptosis-inducing ligand—TNFSF10 (TRAIL), a member of the TNF-α family and a death receptor ligand, was shown to selectively kill tumor cells. Not surprisingly, TRAIL is downregulated in a variety of tumor cells, including BCR–ABL-positive leukemia. Although we know much about the molecular basis of TRAIL-mediated cell killing, the mechanism responsible […]
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Algae holds promise for nuclear clean-up
By Naturenews Common freshwater algae might hold a key to cleaning up after disasters such as Japan`s Fukushima nuclear accident, scientists said yesterday at a meeting of the American Chemical Society in Anaheim, California. The algae, called Closterium moniliferum, are members of the desmid order, known to microbiologists for their distinctive shapes, said Minna Krejci, […]
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Genetics of aging
Agência FAPESP European scientists announced on Sunday (7 / 2) the discovery of genetic mutations associated with aging in humans. The group analyzed more than 500 thousand genetic variants throughout the genome to identify mutations that lie close to the gene called TERC. The news was published in the journal Nature Genetics. Nilesh Samani, professor […]
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The VII Congress of SBBN will address “Radiation in Biosciences: Advances and Prospects.”
The VII Congress of SBBN will address “Radiation in Biosciences: Advances and Prospects.” The central theme of this edition VII is “Radiation in Biosciences: Advances and Prospects.” Addressed in a multidisciplinary approach, will be placed on the agenda and current issues of great interest for Research, Development and Innovation of scientific activities, clinics and technology […]